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[Abstract] Objective: To investigate the EMCOP in the treatment of non-Hodgkin's lymphoma patients. Methods: EMCOP combined with chemotherapy (VP-16, MTN, CTX, VCR, Pred) treatment of non-Hodgkin's lymphoma 30 cases. Among them, the initial treatment in 24 cases, 6 cases of retreatment. And impact of drug toxicity and efficacy factors were analyzed. Results: 30 patients with non-Hodgkin's lymphoma complete remission rate was 66.7%, partial response rate of 23.3%, 90.0% total efficiency, 2-year survival rate of 53.3%. Conclusion: EMCOP program for the treatment of non-Hodgkin's lymphoma chemotherapy better, whether this group of cases in the initial treatment or retreatment are more effective than CHOP program.
[Key words] non-Hodgkin's lymphoma; podophyllotoxin ethylidene glucoside; mitoxantrone
[CLC] R733.4 [Document code] C [Article ID] 1673-7210 (2008) 09 (a) -036-02
Non-Hodgkin's lymphoma (non-Hodgkin's lymphoma, NHL) is a highly heterogeneous group of lymphoid malignancies. Clinically, mostly CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) as first-line combination chemotherapy programs, domestic and international coverage of its 45% complete remission rate was 55%, total effective rate was 70% 90%, 2 to 3 year survival rate was 40% . To further improve the response rate and prolong survival or response time, we EMCOP program combined with chemotherapy NHL 30 patients achieved good effect, are reported as follows:
1 Materials and Methods
1.1 General Information
Our hospital in January 2002 ~ December 2007 to EMCOP in the treatment of NHL 30 patients, all patients were diagnosed by lymph node biopsy NHL.
Introduction in English: Non-Hodgkin's Lymphoma and continue to reflect the heterogeneity of the disease and the biological basis of cell origin of new insights. Course of varying lengths, from no obvious symptoms are resistant to the rapid and early death. In some types of NHL, 50% of the children and about 20% of adult patients with leukemia-like changes. epidemiology in the United States each year, about 50,000 cases of NHL incidence in the 4% of all cancers and all cancers each year in the proportion of deaths caused by NHL accounts for 4%. In the past few decades the incidence of NHL increased stability was sustained growth of 3% each year than most
Non-Hodgkin's lymphoma cancer growth in sub-fast, partly due to the AIDS epidemic, and the other may also be other unknown causes. Italian study on 1388 cases of NHL were analyzed showed immune suppression and HIV prevalence can not explain the NHL's growth trend, while the delayed infection (delayed infection) Th1/Th2 lymphocytes by increasing the damage risk of NHL can be explained by continued growth in the current NHL . NHL patients with bacterial or viral infection for the first time the
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