11:57,28,Jun,2005 | (10782/0/0) | Original
Note: The trackback url will expire after 23:59:59 today
Note: The trackback url will expire after 23:59:59 today
[Abstract] Objective: To investigate the EMCOP in the treatment of non-Hodgkin's lymphoma patients. Methods: EMCOP combined with chemotherapy (VP-16, MTN, CTX, VCR, Pred) treatment of non-Hodgkin's lymphoma 30 cases. Among them, the initial treatment in 24 cases, 6 cases of retreatment. And impact of drug toxicity and efficacy factors were analyzed. Results: 30 patients with non-Hodgkin's lymphoma complete remission rate was 66.7%, partial response rate of 23.3%, 90.0% total efficiency, 2-year survival rate of 53.3%. Conclusion: EMCOP program for the treatment of non-Hodgkin's lymphoma chemotherapy better, whether this group of cases in the initial treatment or retreatment are more effective than CHOP program.
[Key words] non-Hodgkin's lymphoma; podophyllotoxin ethylidene glucoside; mitoxantrone
[CLC] R733.4 [Document code] C [Article ID] 1673-7210 (2008) 09 (a) -036-02
Non-Hodgkin's lymphoma (non-Hodgkin's lymphoma, NHL) is a highly heterogeneous group of lymphoid malignancies. Clinically, mostly CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) as first-line combination chemotherapy programs, domestic and international coverage of its 45% complete remission rate was 55%, total effective rate was 70% 90%, 2 to 3 year survival rate was 40% . To further improve the response rate and prolong survival or response time, we EMCOP program combined with chemotherapy NHL 30 patients achieved good effect, are reported as follows:
1 Materials and Methods
1.1 General Information
Our hospital in January 2002 ~ December 2007 to EMCOP in the treatment of NHL 30 patients, all patients were diagnosed by lymph node biopsy NHL.
Introduction in English: Non-Hodgkin's Lymphoma and continue to reflect the heterogeneity of the disease and the biological basis of cell origin of new insights. Course of varying lengths, from no obvious symptoms are resistant to the rapid and early death. In some types of NHL, 50% of the children and about 20% of adult patients with leukemia-like changes. epidemiology in the United States each year, about 50,000 cases of NHL incidence in the 4% of all cancers and all cancers each year in the proportion of deaths caused by NHL accounts for 4%. In the past few decades the incidence of NHL increased stability was sustained growth of 3% each year than most
Non-Hodgkin's lymphoma cancer growth in sub-fast, partly due to the AIDS epidemic, and the other may also be other unknown causes. Italian study on 1388 cases of NHL were analyzed showed immune suppression and HIV prevalence can not explain the NHL's growth trend, while the delayed infection (delayed infection) Th1/Th2 lymphocytes by increasing the damage risk of NHL can be explained by continued growth in the current NHL . NHL patients with bacterial or viral infection for the first time the
Frequency Xunkan retail price of 540 yuan year / year the retail price of 15 yuan each / Chinese Academy of Medical Sciences of the organizers edited and published the "China Medicine" magazine national reunification International Standard Serial Number ISSN 1673-7210 CN11-5539 / R Youfadaihao 80-372 levy issued outside of the United code TP2705 Code Publication date scheduled in November 2004 Newspaper Publishing date format month 5,15,25 at large overseas, opening price of 16 HK 20 per circulation (per issue) 8000 magazine presents : "Chinese Medicine" magazine is the head of the Ministry of Health, the Chinese Academy of Medical Sciences hosted a national medical and health journals, Department of the Chinese core journals (selection) database, China Academic Journal, Chinese Journal of database technology, the PLA Medical Library database contains full-text periodicals, monthly, and in the latter part of the publication of a domestic and international public offerings, domestic ISSN: CN11-5539 / R, International Issues ISSN1673-7210, Youfadaihao :80-372, priced 15.
"China Medicine" magazine, "Interpretation of medical policies and regulations, development trends of medicine, communication management philosophy, demonstrate medical research, clinical medicine reported progress" for the purpose of the vast number of medical workers to broaden their horizons, to understand the market, learning experience to explore issues, exchange and improve business and academic level of the personal staff assistant, is also published in academic medicine positions. Subscribe, welcome to submit.
"China Medicine" magazine columns established: expert forums, research progress, monographs, short of the experimental research, clinical research, pharmacology and toxicology, drug evaluation, biomedical, pharmaceutical identification, drugs and clinical, Anesthesia and Analgesia , medical tests, pathological analysis, imaging and intervention, Chinese medicine, preparation technology, modern nursing, Education Forum, case reports, misdiagnosis, adverse reaction monitoring, pharmacoeconomics, disease prevention and control, medical equipment, scientific management, pharmacy management, policy research, regulations and standards, industry and market, medical supervision, management, research, work study, health care forum, the cover of more than 30 columns.
"China Medicine" magazine focus on an international leader in innovative scientific research, research projects for the provincial level or above papers and articles first published journal subscribers. According to Ministry of Health "means continuing medical education credits awarded" requirement, published in the journal available to the national continuing medical education credits, this issue may be given to papers published in the paper of the certificate.
Column Description: Expert Forum
By the academicians, academician, national key research projects of academic leaders, doctoral supervisor and other written papers, with new ideas, new ideas, new methods and areas of academic medical research, management and other aspects of academic development some guidance.
Request on the basis of literature review, an overview, analysis, review of the subject areas of new domestic and foreign research results, development of new trends and that their point of view, to subject the development of the forecast, make constructive comments and suggestions. New topics, reasoning and thorough, clear layer, language fluency, with a comprehensive, advanced, evaluating characteristics.
Has high academic value of the field of medicine thesis, highlighting the scientific, innovative and practical. Point clear, reliable information, text, refining, levels of clear, accurate data, experimental design is reasonable, with charts and other visual forms of instructions, diagrams should be self-evidence. Statistically reasonable description specifications; text title concise, eye-catching, to reflect the theme of the article. And communication of the first of 100 words or less can be attached to the personal profile.
Short of the
Question papers set a high academic value, and a certain degree of scientific and innovation. Point clear, reliable information, text, refining, accurate data, experimental design is reasonable, results mainly in the chart shows, and make the appropriate text description, diagrams should be self-evidence. And communication of the first of 100 words or less can be attached to the personal profile.
The field of medicine experimental and theoretical research papers, topics rigorous, argument clear, accurate and reliable data, table design and reasonable. Experimental animals must be marked with the name of research, germ line, grade, quantity, origin, gender, age, weight, feeding conditions and health status. And communication of the first of 100 words or less can be attached to the personal profile.
Main subjects reported clinical diagnosis and treatment, research and application of new therapies. Cases and controls need to account for the source selection criteria and the study of the age, gender and other important characteristics. The contents are new, scientific point of view, data integrity, rational design methods, the results were statistically analyzed to be part of and draw the appropriate conclusions. And communication of the first of 100 words or less can be attached to the personal profile.
Pharmacology and Toxicology
Mainly related to Chinese medicine, Western medicine, Western medicine compound, microbial drugs, biochemical drugs, biological products and biotechnology drugs in preclinical and clinical pharmacology and toxicology studies in experimental research, including animal model and the method of study, pharmacokinetic study (absorption, metabolism, distribution, excretion, etc.), bioavailability of the former drug efficacy studies, drug interactions, and the in vitro testing. And communication of the first of 100 words or less can be attached to the personal profile.
Pharmaceutical Biotechnology R & D reports (including new technology, new achievements, new products, new patents) and promote the use of the original paper, introducing the production technology, operating techniques, laboratory tests and other technical improvements and Methods. And communication of the first of 100 words or less can be attached to the personal profile.
Mainly include traditional Chinese medicine and natural medicine, the active chemical components of the extraction, separation, identification and chemical structure determination; chemical synthesis of drugs and technical improvements (including synthetic drugs and antimicrobial agents in the semi-synthetic and fully synthetic, purification and structure identification technology); microbial drugs fermentation, extraction, refining, component separation, identification; biochemical medicine, biotechnology, pharmaceutical separation, purification and structure identification. Western compound in the composition of the qualitative, quantitative, and test analysis, drug analysis methods (new methods, new technology and new equipment, etc.). And communication of the first of 100 words or less can be attached to the personal profile.
Drugs and clinical
Main drug coverage (including an old drug new use) clinical trials, clinical application, drug treatment, rational drug use, interaction and drug evaluation. On the need for rational design methodology, some results were statistically analyzed and the corresponding conclusions, careful examination of the body text of the drug dose, the number of cases, the percentage of such data. And communication of the first of 100 words or less can be attached to the personal profile.
Anesthesia and Analgesia
Focuses on domestic and international clinical anesthesia medication and technology, methods and effects of analgesic therapy. Requires a clear argument, arguments, reliable, accurate figures, refining the text, using appropriate statistical methods to analyze and then draw conclusions. And communication of the first of 100 words or less can be attached to the personal profile.
Mainly reported biochemical, clinical testing, microbiological testing, immunoassay and other aspects of medical examination and cross-disciplinary research, theoretical discussion, cutting-edge technology and work practices and experience. And communication of the first of 100 words or less can be attached to the personal profile.
Concerning the preoperative diagnosis of biopsy pathology, body fluids, secretions, biopsy material, exfoliated cells in pathological diagnosis, autopsy pathology diagnosis, pathological diagnosis, rapid paraffin section, introduced disease mechanisms and clinical pathophysiology.
Imaging and Intervention
Main report of Radiation Medicine (including CT, MRI, general X ray), Ultrasound in Medicine, Interventional Therapy, imaging technology, electronic endoscopy, nuclear medicine and other disciplines of the latest research, theoretical discussion and practical work experience. And communication of the first of 100 words or less can be attached to the personal profile.
Reported in the medical field mainly the latest research results. Include: traditional Chinese medicine research and development, Integrative Medicine Clinical study of various diseases, the traditional New Clinical by side, acupuncture and massage of the modern research and clinical experience.
Preparation and Technology
Pharmacy and the main report's experimental drug production technology research, involving natural medicine, Chinese medicine (traditional formulations and new dosage form), synthetic drugs, microbial drug production process (including production Strain); biochemical medicine, biotechnology drugs, biological products of the production process; pharmaceutical raw materials, intermediates, antimicrobial agents and the side chain precursor, preparation and extraction of resin and other materials production process; drugs (wood) synthesis, extraction, formulation and process research, stability research and studies of new formulations. And communication of the first of 100 words or less can be attached to the personal profile.
Hot spots include nursing, nursing research, basic care, specialized care, rehabilitation care, emergency care, preventive care, community care, experience and innovation, health education, nursing education, nursing management.
Explore new ideas in medical education, new methods, new technology papers, including the administration of medical colleges, school characteristics, and status of education reform, teaching management, education research study, elite culture and so on. Reported that medical institutions and medical research institutes for teachers and educational administrators to explore medical disciplines in education, teaching reform process of the new ideas, new practices and their effects, as well as domestic and foreign reports the latest achievements in medical education and medical fields related to subject building.
The main report and supplementary sections of the department of clinical diagnosis and treatment encountered in rare, rare case, including diseases, clinical manifestations are not common, rare adverse drug reactions, as well as a new disease or clinical events occurred in the first report .
Clinical work reported in the main causes of misdiagnosis and mistreatment of various cases of misdiagnosis factors, to arouse the attention of the general clinical health workers to reduce the recurrence of similar incidents.
Adverse reaction monitoring
Mainly the monitoring of adverse drug reactions reported cases of adverse reactions to factors descriptive, analytical, experimental or investigative studies. Summary of adverse drug reactions should be more randomized controlled clinical trials, cohort studies or case-control study based on both rare cases of adverse reactions reported to promote systematic review. Also reported that drug-induced disease diagnosis and prevention and control.
Including drug treatment and other treatment or drug treatment programs have different economic - The Comparative Analysis, in particular, drug imports and domestic drugs, new drugs and old drugs, special agents and general agents of the comparison; single disease drugs analysis cost - effectiveness analysis, cost - effectiveness analysis and cost - benefit analysis. And communication of the first of 100 words or less can be attached to the personal profile.
Disease Control and Prevention
Prevention and control of major areas of medical reports of new theories, new technology, new achievements and new methods. Particularly in relation to public health emergencies, public health monitoring and service improvement, progress in prevention and control of communicable diseases and so on. Include: labor hygiene, sanitation, nutrition and food hygiene, child adolescent health, radiation health, health toxicology, epidemiology, disease surveillance and immunization, disease prevention and health promotion, health care and health chemicals and Inspection and other aspects of scientific research and effective prevention and treatment experience.
Mainly reported medical equipment, reagents, materials, product development, manufacturing, clinical applications, market analysis and forecasting, and other related aspects.
Investigate and report on management of medical research and progress within the research to the national health administration, medical colleges, hospitals, health and epidemic prevention agencies and leading research institutions, research administrators and management activities involved in medical research experts in other disciplines, scholars, academic researchers and technology developers as the main target, the report discuss the theoretical methods of scientific research management, scientific and technological cooperation and exchanges, subject construction and technology talent management, learning dynamics and domestic and international research on the market. Presentation content should be scientific, logical, and theoretical and practical significance, refining the text to be accurate, fluent and focused.
Concerning the quality of management experience in pharmaceutical production and discussion of drug quality standards and quality checks of the results of the analysis, drug storage, storage, supply and business management experience, drug research, development, approval, protection, patents, national essential drug list, the State basic medical insurance drug list, prescription drugs and non-prescription drugs, out of variety of management experience, pharmaceutical organizations (government agencies, societies, information agencies, pharmacies, pharmacy, education and training, etc.) and pharmacists in the work of the problems found and the related views and recommended, pharmaceutical analysis and other policies and regulations.
Main areas of coverage for major national health policy development and adjustment, as well as the effect of the implementation, problems encountered and rationalization recommendations. Include: medical and health service system reform, medical price adjustment, health economics, the implementation of social health insurance, health care medical administration, health services administration information, health management, supervision and reporting of information policy. Involving medical, pharmaceutical, medical advertising management, health management. Higher contributions required political and ideological content, analysis and thorough, profound, words appropriate to express simplicity.
Regulations and standards
Existing laws and regulations of the field of medicine and a variety of standards and the inadequacy of measures to improve; reported that the field of medicine recently enacted laws and regulations, and specific projects to develop the appropriate standards in the implementation of its results, questions, suggestions, etc. to interpret. Include: Drug Registration Regulation, administrative rules and regulations of medical pharmaceutical, medical and health service standards and administrative regulations to prevent commercial bribery, medical, health economic regulations, drug and food hygiene standards, drug advertising regulations, health care laws and regulations and so on. Higher contributions required political and ideological content, analysis and thorough, profound, words appropriate to express simplicity.
Industry and Market
Mainly reported on the pharmaceutical industry and market sector analysis, management, market research, marketing strategy and industry dynamics and so on.
The quality of medical care, health care reform, hospital management of various departments, pharmacy management, hospital culture, talent management, implementation; of drug supervision and management, basic drug management, drug storage management, drug price regulation, health insurance agents and fixed-point pharmacy management, pharmaceutical research and development quality control, drug production and operation of quality control, quality control of pharmaceutical care, medical insurance, pharmacy drug sales management activities, problems and countermeasures.
Reports on the medical and health sector management theories, methods, personnel managemen
Reports and medical and health, health-related research reports, including health statistics, surveys and statistical physical development, life survey and research, investigation and research of disease, drug-related investigation and research.
Reported that the work of the pharmaceutical industry-related positions, including management practices, research and ideas, learning and education methods.
Health Care Forum
Reported health care experiences in clinical work and experience.