06:17,5,Aug,2008 | (1077/0/0) | Original

powerpoint presentation langerhans cell histiocytosis


Langerhans cell histiocytosis of clinical and pathological analysis of 20 cases
Langerhans cell histiocytosis
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powerpoint presentation langerhans cell histiocytosis

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Condition analysis:
Low-risk age group> 2 years old, hematopoietic system, liver, lung or spleen were not violated. Risk group Age <2 years old, or with violations of the aforementioned organ. Due to illness persists, patients often can not be strictly designed according to the program, with treatment therefore, there may be symptoms of a variety of organ involvement (Table 137-2). In 0 ~ â…¡ group of patients, especially those patients with single system disease, almost no systemic therapy, while almost no disability, nor cause death. Some groups â…¡ and â…¢ majority (ie, with multi-system disease), the need for systemic therapy, but generally still valid. â…£ group of young and the more systematic violations of patients, morbidity and mortality rates as high as 20% , despite the recurrence of common, but almost all can be effective for patients with good final stop treatment. in adult patients with chronic conditions may render the process of ups and downs.
Heavy patients should be hospitalized and to the maximum dose of antibiotics to keep the airway, nutritional support (including high-energy nutrition), blood products, skin care, physical therapy and the necessary medical care. Stringent hygiene measures can effectively reduce the auditory canal, skin and gums damage. Shixing Qing debridement, or even serious damage to the gum tissue resected to limit the oral lesions. scalp seborrheic dermatitis can use quality shampoo selenium (2 times per week). If the shampoo does not work, a small amount of local use of corticosteroids chemical agents in the short term control of small lesions. of diabetes insipidus or other symptoms of pituitary dysfunction in patients with most of the required supplementary hormone treatment.
Suggestion:
Local treatment (surgery and radiotherapy) in the complete assessment, a single bone violations and in some cases, patients with multiple site damage in patients, use of local therapy. In patients with superficial lesions, in accessible and non- dangerous position, may be an operation curettage. but to avoid excessive surgery in orthopedic and plastic surgery, and damage functions. radiotherapy (using high voltage devices) often given to skeletal deformities, exophthalmos due to vision loss, pathologic fractures, spinal compression and spinal cord injury or severe pain, or lymphadenopathy patients.
Chemotherapy in low-risk patients> 2 years old, with single system disease, or a
part of the bone or parts of bone damage, often given to local treatment without systemic therapy. However, the treatment fails, or elevated erythrocyte sedimentation rate may indicate a serious continuous The existence of systemic diseases. low-risk patients> 2 years with multi-system disease, but not violations of the blood system, liver, lung or spleen, may be given chemotherapy, often sustained effect, but most of the <2 years old, the foregoing violations of organ systems , particularly disorders in children, although given chemotherapy but died.
Very poor prognosis for patients in the diagnosis of HLA matching should consider a bone marrow transplant, cyclosporine or experimental immunosuppressive or other immunomodulating therapy.
In the systemic Langerhans cell histiocytosis patients, and treatment of the disease can cause chronic disability, such as cosmetic or functional orthopedic and skin disease damage and neurotoxicity, and should be monitoring the mood swings .
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