15:29,18,Dec,2009 | (1634/0/0) | Original

pathophysiology of laryngeal cancer


Abstract: Objective ginsenoside Rh2 and cisplatin (Cisplatin, DDP) combination on laryngeal carcinoma cells Hep-2's role. Methods Cultured Hep-2 laryngeal carcinoma cells were added to a final concentration of 0.5,1.0,2.0,5.0 μg / ml of DDP, a final concentration of 10,20,30,40 μg / ml of Rh2, and the final concentration of 20μg/ml of the joint final concentration of Rh2 were 0.5,1.0,2.0,5.0 μg / ml of DDP, blank control group until 48 hours after drug, respectively, with an optical microscope , MTT, flow cytometry (Flow cytometry, FCM), fluorescence microscopy of cultured cells effect. The results can be seen under the light microscope the growth of normal laryngeal cell density, cells were spindle or polygonal cells in contact with each other. Rh2 in the low dose group and DDP group, showing a slight decrease of cell number, cell morphology did not change significantly. Rh2 in the high dose group and DDP group, cell number was significantly reduced, showing cell debris. While the low dose and low dose DDP Rh2 in combination, the availability and the high dose group and DDP group Rh2 same effect. MTF results showed that Rh2, DDP alone and in combination were tested dose dependent increase in cell growth inhibition of laryngeal cancer. Rh2 low dose and low dose DDP in combination, can inhibit the growth of laryngeal cancer cells. FCM showed Rh2 and DDP alone, can induce apoptosis, while the combined availability of more obvious than that alone induce apoptosis effect. Acridine orange staining showed that the treatment group were seen budding cell membrane, chromatin condensation, nuclear fragmentation and apoptotic bodies and other typical features of apoptosis. Conclusion Ginsenoside Rh2 and DDP can induce apoptosis in laryngeal cancer cells, the two combined to reveal a synergistic effect, can play a more significant role in cancer.
pathophysiology of laryngeal cancer

Central South University Admissions Information Admissions Department Name Major Name Year research notes to be subject of examination in 2009 enrollment Pathology and Pathophysiology, Central South University, 01 digestive tumor pathology (Department of Pathology, Department of Pathology, Xiangya Hospital) 02 lung tumor pathology (disease Faculty of Science, Department of Pathology, Xiangya Hospital) 03 silicosis Science (Department of Pathology, Department of Pathology, Xiangya Hospital) 04 Clinical Pathology (Department of Pathology, Department of Pathology, Xiangya Hospital) 05 Ultrastructural Pathology (Medical Ultrastructure Ultrastructural Pathology Lab) 06 septic shock (Pathophysiology) 07 cardiovascular pathophysiology (Pathophysiology) 13 â‘  101 political â‘¡ 201 Integrated Traditional and Western English â‘¢ 306 (657) Central South University Admissions Information Admissions Department Name Major Name Year research Notes to be
subject of examination in 2009 enrollment Pathology and Pathophysiology, Central South University, 01 02 the molecular mechanism of nasopharyngeal cancer genomics and transcriptomic 03 the molecular mechanism of tumor invasion and metastasis 04 signal transduction mechanism of tumor cancer proteomics research 06 05 tumor markers and targeted therapy of 07 tumor antibody engineering and immunotherapy 08 cancer stem cell research â‘  101 political â‘¡ 201 English â‘¢ 306 TCM and Western medicine (662) Central South University Admissions Information Admissions Year Department Name Major Name of the direction of intended enrollment examination subjects Notes 2009 South Africa Pathology and Pathophysiology, University of 01 02 malignant liver cancer proteomics study of pathogenesis of laryngeal cancer incidence 03 04 molecular mechanism of gastrointestinal cancer, liver fibrosis, the mechanism of political â‘¡ 201 â‘  101 English â‘¢ 306 TCM and Western medicine (810) Central South University Admissions Admissions Department Name Major Name Year research notes to be subject of examination in 2009 enrollment Pathology and Pathophysiology, Central South University, 01 breast, 02 metabolic bone disease pathology of lung cancer pathology, tumor Pancreatic endocrine tumors 03 04 lymphoid, hematopoietic 05 common malignant tumor study Screening of molecular markers of political â‘¡ 201 â‘  101 English â‘¢ 306 TCM and Western medicine (822) Central South University Admissions Information Admissions Department Name Major Name Year research notes to be subject of examination in 2009 enrollment Pathology and Pathophysiology, Central South University 01 pathological 02 clinical pathology â‘  101 political â‘¡ 201 English â‘¢ 306 TCM and Western medicine (831) Central South University Admissions Information Admissions Year Department Name Major Name of the direction of intended enrollment examination subjects Notes 2009 Central South University, Pathology and Pathophysiology 01 tumor pathology â‘  101 political â‘¡ 201 English â‘¢ 306 TCM and Western medicine (901) Current 1 / 1 page Home Previous Next End
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