02:30,8,Jul,2007 | (1245/0/0) | Original

microcytic hypochromic anemia


Abstract: Objective red blood cell distribution width (RDW)-CV and RDWS-D relationship between the results in order to identify RDW-SD of clinical applications. Methods based on the first Association for Clinical Laboratory Standards (CLSI) C28-A2 guidelines established reference intervals between the two, the population distribution curve of the two, and then the 121 randomized clinical specimens, 109 specimens and 25 cases of Mediterranean anemia of iron deficiency Determination of anemia RDW-CV samples and RDWS-D, and according to the reference range for both the increase and reduce the comparative analysis of the situation. Results RDW-CV in the normal population close to the normal distribution, RDWS-D showed a skewed distribution. RDW-CV and RDW-SD does not increase or decrease between the line, RDW-CV increased or normal specimens of its RDWS-D may appear higher, normal or reduced, RDW-CV specimens reduced the RDW-SD may also be the normal or lower, the two patients in the random coincidence rate was 80.0%. Iron deficiency anemia in patients with RDW-CV and RDW-SD than the average high-thalassemia (P <0.001), but between the two patients with thalassemia distribution parameters between patients with iron deficiency anemia than the distribution width and the distribution of iron deficiency anemia included. Mediterranean anemia and iron deficiency anemia in patients with the results of most of the RDW-CV were increased, a small part of the normal range. RDW-SD thalassemia results can be increased, normal or reduced, and to reduce the main, and RDW-CV was "upside down" phenomenon, and iron deficiency anemia who were not decline. Conclusion Combined detection of RDW-CV and RDW-SD can be more fully reflect the heterogeneity of RBC, and Mediterranean anemia and iron deficiency anemia in the differential diagnosis to a certain extent.
microcytic hypochromic anemia

Hypochromic anemia of small cells include: (1) iron deficiency anemia: this refers to a variety of reasons that make the body store of iron consumption idle, the mature red blood cells affected by anemia. Characterized by bone marrow, liver, spleen and other tissues lack of iron staining. Serum ferritin, serum iron and transferrin saturation decreased. (2) generated anemia globin: β-thalassemia major is the severe and light β-thalassemia, HbH disease. They often have a family history, blood film shows the majority of target-shaped red blood cells, showing that fetal hemoglobin (HbF) or hemoglobin A2 (HbA2) or HbH increased. Serum iron, transferrin saturation, iron staining of bone marrow may have increased. (3) sideroblastic anemia: a variety of causes, including hypochromic anemia. Barriers to use of synthetic hemoglobin and iron poor, accompanied by red blood cell anemia void generation is such a common mechanism. The common characteristics of Hematology sideroblasts in the bon
e marrow increased significantly, many of which cells are arranged around the iron pellets in the nuclear ring, the peripheral blood showed a low red blood cell pigment characteristics, serum iron concentration was significantly higher, single- Nuclear - macrophages was significantly increased hemosiderin. It can be divided into: â‘  hereditary sideroblastic anemia: very rare. Anemia may also include several of these genetic effects are not the same type and treatment of anemia. â‘¡ acquired sideroblastic anemia: it is divided into primary, concomitant drugs or poisons, and other diseases associated with. Primary sideroblastic anemia, also known as refractory erythroblastic anemia. The anemia is more rare, especially rare in China. There are some cases of pyridoxine treatment of a better effect. (4) transferrin deficiency: also known as non-transferrin, albumin, is due to genetic defects in the plasma in the absence or lack of transferrin. Liver, spleen, pancreas, a large number of iron piling, and no use of iron in the bone marrow to synthesize hemoglobin. This disease is very rare. (5) Primary pulmonary hemosiderosis and lung and kidney bleeding disorder syndrome: primary pulmonary hemosiderosis is a rare disorder of iron metabolism disorders, characterized by a wide range of pulmonary capillary bleeding, There are a large number of alveolar hemosiderosis, accompanied by iron deficiency anemia. The main clinical manifestations of recurrent hemoptysis, shortness of breath and anemia. Also known as Goodpasture syndrome, lung and kidney bleeding syndrome is a rare disease. And primary pulmonary hemosiderosis similar disease, characterized by alveolar hemorrhage is also a recurrent and iron deficiency anemia, but there is glomerular nephritis and performance. 6) and other chronic infectious anemia: anemia of chronic infection, although the decrease in serum iron, total iron binding capacity but does not increase or decrease, so the transferrin saturation, normal or slightly increased. Serum ferritin is often higher. Sideroblastic bone marrow cells decreased, hemosiderin granules increased significantly. Others, such as lead poisoning, there may be small cell hypochromic anemia.
Hypochromic anemia of small cells include:
(1) iron deficiency anemia: this refers to a variety of reasons that make the body store of iron consumption idle, the mature red blood cells affected by anemia. Characterized by bone marrow, liver, spleen and other tissues lack of iron staining. Serum ferritin, serum iron and transferrin saturation decreased.
(2) generated anemia globin: β-thalassemia major is the severe and light β-thalassemia, HbH disease. They often have a family history, blood film shows the majority of target-shaped red blood cells, showing that fetal hemoglobin (HbF) or hemoglobin A2 (HbA2) or HbH increased. Serum iron, transferrin saturation, iron staining of bone marrow may have increased.
(3) sideroblastic anemia: a variety of causes, including hypochromic anemia. Barriers to use of synthetic hemoglobin and iron poor, accompanied by red blood cell anemia void generation is such a common mechanism. The common characteristics of Hematology sideroblasts in the bone marrow increased significantly, many of which cells are arranged around the iron pellets in the nuclear ring, the peripheral blood showed a low red blood cell pigment characteristics, serum iron concentration was significantly higher, single- Nuclear - macrophages was significantly increased hemosiderin. It can be divided into:
â‘  hereditary sideroblastic anemia: very rare. Anemia may also include several of these genetic effects are not the same type and treatment of anemia.
â‘¡ acquired sideroblastic anemia: it is divided into primary, concomitant drugs or poisons, and other diseases associated with. Primary sideroblastic anemia, also known as refractory erythroblastic anemia. The anemia is more rare, especially rare in China. There are some cases of pyridoxine treatment of a better effect.
(4) transferrin deficiency: also known as non-transferrin, albumin, is due to genetic defects in the plasma in the absence or lack of transferrin. Liver, spleen, pancreas, a large number of iron piling, and no use of iron in the bone marrow to synthesize hemoglobin. This disease is very rare.
(5) Primary pulmonary hemosiderosis and lung and kidney bleeding disorder syndrome: primary pulmonary hemosiderosis is a rare di
sorder of iron metabolism disorders, characterized by a wide range of pulmonary capillary bleeding, There are a large number of alveolar hemosiderosis, accompanied by iron deficiency anemia. The main clinical manifestations of recurrent hemoptysis, shortness of breath and anemia. Also known as Goodpasture syndrome, lung and kidney bleeding syndrome is a rare disease. And primary pulmonary hemosiderosis similar disease, characterized by alveolar hemorrhage is also a recurrent and iron deficiency anemia, but there is glomerular nephritis and performance.
6) and other chronic infectious anemia: anemia of chronic infection, although the decrease in serum iron, total iron binding capacity but does not increase or decrease, so the transferrin saturation, normal or slightly increased. Serum ferritin is often higher. Sideroblastic bone marrow cells decreased, hemosiderin granules increased significantly. Others, such as lead poisoning, there may be small cell hypochromic anemia.
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