06:16,14,Nov,2010 | (340/0/0) | Original
Note: The trackback url will expire after 23:59:59 today
Note: The trackback url will expire after 23:59:59 today
Location: Xunyiwenyao> ganciclovir to prevent cytomegalovirus baby (Cmv) deterioration of hearing loss associated with ganciclovir to prevent cytomegalovirus baby (Cmv)-related deterioration of hearing loss
Article Posted by: Source: Xunyiwenyao net collections this SAN FRANCISCO (Reuters Health) - Ganciclovir can prevent hearing loss or progression of hearing loss in infants with symptomatic congenital cytomegalovirus (CMV), according to the results of a study presented at the American Academy of Pediatrics 2001 national conference and exhibition.
Since 58% of infants with symptomatic congenital CMV will develop sensory hearing loss, Dr. David W. Kimberlin, of the University of Alabama at Birmingham, said that based on the study findings "ganciclovir should be considered for treatment of symptomatic congenital CMV."
Dr. Kimberlin and colleagues with the National Institute of Allergy and Immunology Collaborative Antiviral Study Group evaluated 100 infants over a 9-year period. All but two infants were younger than 30 days at enrollment and two were enrolled at 33 days.
Because ganciclovir is a "highly toxic drug," the study enrolled "only the worst of the worst," in terms of CMV complications. Children were randomized to either 6 weeks of IV ganciclovir 12 mg / k per day or no treatment. Both groups were monitored for 12 weeks and followed at 6 months, 1 year and 2 years, he said.
The primary endpoint was improved brain stem-evoked response by one gradation, or maintenance of normal hearing. Secondary endpoints were either biologic hearing, measured by hearing in both ears, or functional hearing, measured by "best ear" hearing, he said.
He said that the findings were based on 44 assessable patients. At 6 months, "85% of the 25 ganciclovir-treated children had improved or maintained their hearing. None had worsening hearing," he said. Forty-four percent of the children in the untreated group had improved or maintained hearing at 6 months.
At 2 years, 52% of the ganciclovir children improved or maintained hearing compared with 25% of the children in the no treatment group, he said. Moreover, at 2 years, 70% of the children in the no-treatment group "had worsening hearing compared [with] 20% in the ganciclovir group, "he said.
Ganciclovir improvement was "apparent at 19 days," said Dr. Kimberlin. An interesting finding was that at 6 weeks the ganciclovir children "had greater weight gain and greater gain in head circumference." But he said that change was not sustained at 6 months or after. "It may reflect the really different treatment these children received because they were hospitalized during those 6 weeks," he said.
He noted, however, that two thirds of the children treated with ganciclovir "developed grade 3-4 neutropenia compared with just one fifth of the children in the no-treatment group."
Dr. Kimberlin said that in December the NIH would begin a dosing trial of orally available valganciclovir fo
He said the NIH estimates that in the US 40,000 children are born with CMV each year. "Of those, about 2800 are symptomatic at birth and 336 have fatal disease. The number who will have sequelae is estimated at 2160."
About 5500 of the asymptomatic children will also develop CNS sequelae, he said, "so the total number of children affected each year is about 8000." The costs associated with caring for those children are about $ 1.86 billion, he added.
-Westport Newsroom 203 319 2700 (Article Source: good doctor) Related Views: issues related to information-related diseases more>> read this article also read the users? Guangdong Development of pandemic influenza virus diagnosis. Prevention of neck and low back pain in the top five. Big haircut on China related to a 106 stem. "Prostate disease" and the rehabilitation. Garlic is to prevent a flow of babies. Menopausal you need to prevent what. eat boiled corn actually prevent diabetes. Q & A Featured More>> CMV antibodies IGM CMV. cytomegalovirus antibodies IGM CMV. CMV [cytomegalovirus] - IgM negative . Cytomegalovirus IgM (CMV IgM) as. to check cytomegalovirus, drug ganciclovir to 7 days. four months of infants infected with CMV cytomegalovirus (IGM ). cytomegalovirus infection in children 4 months, only hearing . Community hot topic more>> Thank God I eventually got premature ejaculation a few simple lunch sitting betray your libido do not know what to eat? We too have the same wife I do not do that, actually Secret with others in 15 daily magic of food assistance, sexual intercourse without ejaculation, how do ah my treatment of severe cervical erosion experience to do the following 12 to let you bid farewell to infertility
Similar documentsã€‘ ã€China Academic Journal Luo know before the 10 1 Valley, Zhang Wenbin, Han Yunlong; case of intrauterine infection of epidemic hemorrhagic fever (Abstract) [J]; Fourth Military Medical University; 1981 03 2 Liu Shulin;; intrauterine the immunological consequences of infection [J]; International Journal of Immunology; 1982 01 3 SU first lion, Xing-wide, Chen Yide, Yang, Zhang Heroes; intrauterine infection of hepatitis B [J]; Journal of Clinical Research; 03 1985 Lu Yao set of 4; A Li Chi, MD [J]; new medicine; 1985 02 5 Yan Xinyu; weeks Vichy; Guo Dafen;; hepatitis B virus (HBV) intrauterine infection in [J]; Luzhou Medical College; 1986 01 6 Nie Jun, ZHAO Xiao-li, Dai Zaisen, Wang Yaxian, Cheng Shaoyao; hepatitis B virus intrauterine infection report of two cases [J]; First Military Medical University; 1987 02 7 Yang Shuqing, Peng Wenwei, Hebi Fen; hepatitis B virus Palace The incidence of infection and mechanism [J]; Sun Yat-sen University (Medical Sciences); CHONG 1989 02 8 red; Blue Wing Ying;; Progress in hepatitis B virus intrauterine infection [J]; Guangxi Medical; 1989 03 9 Liupei Li, ZHOU Ling, Yang Yu-Fang, Development Thought, Wang Jiao Yang; maternal intrauterine infection of HCMV [J]; Chinese Journal of Reproductive Health; 1990 01 10 Liu Gang; Liu Foucault; Guxiang Tian;; hepatitis B virus intrauterine infection Survey [J]; Shandong Medical College; 1990 01 important meetings in China before the full paper 10 1 Han Xiaobing database; Yue Yafei; Zhang Shulin;; intrauterine infection of hepatitis B virus - nested PCR, Detection of HBV DNA [A]; '96 Conference of the National Conference of Eugenics in academic lectures and Abstracts of the General Assembly, [C]; 1996 2 Wanghai Qi; Shao Yanan; Jianning; Zhen-Qing Feng;; Toxoplasma infection are prone to cause intrauterine growth of fetal abnormalities [ A]; '96 Conference of the National Conference of Eugenics in academic lectures and Abstracts of the General Assembly, [C]; 1996 3 Wu Jinsong; Ma Xianxiong;; PCR technique and enzyme-linked immunosorbent assay diagnosis of intrauterine infection compared the sensitivity and reliability of [ A]; '96 Conference of the National Conference of Eugenics in academic lectures and Abstracts of the General Assembly, [C]; 1996 4 Zhoushi Yuan; Yan British land; Tianxian Zhi; cattle into Ling; Cao Huili;; hepatitis B virus intrauterine infection and its related factors [A]; of the Fifth National Conference of Eugenics Paper Series [C]; 2000 years 5 LIU Yan-qiu; YU Shi-Rong; Rowan; Koelreuteria Qing; Li Yu in;; Toxoplasma history of intrauterine infection and adverse pregnancy relationship between [A ]; the Fifth National Conference of Eugenics Paper Series [C]; 2000 6 Xu Jianqiu; Yu Chunzhi; Liu Xiaoying; doors;; Antenatal hepatitis B immune globulin hepatitis B virus intrauterine infection blocking studies [A]; mark of excellence Lin Qiaozhi people physician 100th anniversary of the doctor - National Senior Academic Obstetrics and Gynaecology Forum Proceedings [C]; 2001 7 Su Haixia; Yan Yongping; Zhong Xu; Li Duan; Lu Juan;; hepatitis B virus before the C / C and the former S / S gene heterogeneity and its preliminary study on the relationship between intrauterine infection [A]; building a moderately prosperous society: the historical responsibility of scientists in China - China Association 2003 Annual Conference Proceedings (under) [C] ; 2003 8 Li Xiaojie; Gao Jing;; intrauterine infection in premature rat animal model of brain injury in experimental study [A]; of Rehabilitation Medicine Conference will be the first children's rehabilitation Rehabilitation of the Disabled Association and the China Academic eighth cerebral palsy Conference Papers Series [C]; 2004 9 Su-Hua Chen; smell good Jane; Xiongjin Wen;; Jinye Baidu Chinese cytomegalovirus intrauterine infection prevention and control of animal experiments and clinical research [A]; China Association of Eugenics Eugenics in 2004, the academic Exchange Conference Proceedings [C]; 2004 years 10 Qian Chen; Sun Feng cell;; clinical analysis of 459 cases of intrauterine infection [A]; Journal of Obstetric Medicine of the Second National Seminar on Hot Issues Forum and the first director of the National Obstetric Conference Papers Series [C]; 2004 full-text database of China's major newspapers before the 10 1 Jiang Wei; prenatal and postnatal intervention of hepatitis B virus from whole baby [N]; China's tax report; 2000 2; prenatal diagnosis and treatment of ABO hemolytic [ N]; Guangdong Science and Technology Report; 3, 2000, Qian Hai-hong; your child from hepatitis B [N]; Health News; 2000 4 reporter Wang Xuefei; cytomegalovirus infection during pregnancy can be diagnosed [N]; Health News; 5, 2000 PLA 302 Hospital Dr. Liu Shijing; hepatitis B both mother and child, but also has a parent child transmission [N]; China Pharmaceutical News; 6 2000, Xiao-Cui WANG Shu-yun; pregnant women take a bath with stress [N]; Hubei Science and Technology News; 2001 7; mother to child transmission of hepatitis B What means? [N]; Science and Technology Daily; 2001 8 Liu Zhengying; abortion should not be too much medical abortion [N]; National Pharmaceutical News; 9, 2001 Reporter YANG Ke; birth defects quickly intervene in [N]; Chinese consumers ; 2001 10 Teng Xiaochun; pregnancy pregnancy to prevent "poisonous" [N]; economic medicine; PhD thesis in 2001 before the full-text database 1 10 Cao Bao flowers; annexin V and FcÎ³ receptor distribution in the placenta and â…¢ with intrauterine infection of HBV [D]; Fourth Military Medical University; 2004 2 Gu Shaoqing; cell factor gene polymorphisms and hepatitis B virus intrauterine infection related research [D]; Fudan University; 2004 3 Shaozhong Jun; hepatitis B virus intrauterine infection risk factors [D]; Fourth Military Medical University; 2005 4 WORKER; HBVF vitro infection of human placental trophoblast cells and promote the role of TNFÎ± [D]; Fourth Military Medical University ; 2005 5 Liu Yumei; cytokine IL-6 and IL-10 in preterm labor with chorioamnionitis in the correlation [D]; Sichuan University; 6 Xu Zhihong, 2005; infection in premature AP-1 chemotaxis factor regulation and inhibition of curcumin [D]; Sichuan University; 2006 7 Li Liping; placental factor in HIV-1 vertical transmission through the placenta of the role of [D]; Jinan University; 2006 8 Chen Suqing; Hepatitis B immune globulin to prevent hepatitis B virus intrauterine infection in [D]; Fudan University; 2005 9 Ge Yanling; IL-2 and IL-12 gene polymorphisms and susceptibility to intrauterine infection of HBV [D]; Fudan University; 10, 2006, New Po Xie; HBV pre C region and C promoter mutation and prenatal intrauterine infection and block the relationship between [D]; Fudan University; master's degree in China in 2006 before the database full paper 10 1 Guo Pei Fen; hepatitis B virus (HBV) intrauterine transmission and immune changes before and after the HBV S gene of [D]; First Military Medical University; 2001 2 Su Haixia; hepatitis B virus C / C and the former S / S gene heterogeneity and its preliminary study on the relationship between intrauterine infection [D]; Fourth Military Medical University; 2003 3 Yang Shuli; pregnant hepatitis B virus (HBV) carriers and fetal tissues and cells and significance of HBV markers [ D]; Third Military Medical University; 2003 4 Features and Humanity Features; HLA-DR antigen and HBV mutations in the HBV intrauterine infection in the sense of [D]; Shanxi Medical University; 2002 5 Shi Xiaohong; HBV replication in peripheral blood mononuclear cells status, and the intrauterine infection of HBV [D]; Shanxi Medical University; 2003 6 Yuantian Ming; intrauterine Escherichia coli infection leads to white matter damage in rat experimental study [D]; Zhejiang University; 7 Liu Yiping, 2004 ; hepatitis B virus intrauterine infection in follow-up study [D]; Fourth Military Medical University; 2004 8 Wang Xinyu; intrauterine infection on the pathogenesis of fetal brain injury research and protective effect of dexamethasone [D]; Chinese medicine University; Ni Wei Jun 9, 2004; HUM TH01, GSTM1 and ACE gene polymorphism and genetic mechanism of HBV intrauterine infection [D]; Shanxi Medical University; 2004 10 Shu-Zhen Li; hepatitis B virus genotype and "a" determinant Relationship between mutation and HBV intrauterine transmission of [D]; Shanxi Medical University; 2005
Abstract: Objective: To analyze the cytomegalovirus (CMV) hepatitis in children with hearing loss and to explore ganciclovir for CMV hepatitis, hearing loss treatment. Methods: 103 patients with CMV hepatitis were randomly divided into treatment group (65 cases) and control group (38 cases). Ganciclovir treatment group, supplemented by protecting liver gallbladder and other symptomatic treatment, the control group, only symptomatic treatment such as use of Liver gallbladder. Periodic inspection routine, routine biochemistry, blood and urine CMV-pp65 CMV-DNA, detection of brainstem auditory evoked potentials (ABR). Results: The treatment group before and after treatment in children with CMV-pp65, CMV-DNA positive rate was statistically significant difference between (P <0.01); control group before and after the CMV-pp65, CMV-DNA positive rate of urine showed no s