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Abstract Objective: To investigate the acute lymphoblastic leukemia (ALL) patients before and after the platelet count (PLT), mean platelet volume (MPV), platelet volume distribution width (PDW) and platelet hematocrit (PCT) and its clinical significance. Methods: BKM Ac.T 5diff automatic blood cell analyzer 67 patients with acute lymphoblastic leukemia patients before chemotherapy and after treatment of bone marrow suppression, bone marrow recovery early, complete remission PLT, MPV, PDW, PCT and in 50 cases the results healthy people PLT, MPV, PDW, PCT values as controls. Results: Before chemotherapy, patients with ALL PLT, MPV, PCT values were significantly lower than the control group (P0.05). Bone marrow suppression after chemotherapy of PLT, PDW, PCT was significantly lower than that before chemotherapy (P0.05). Conclusion: PLT, MPV, PDW and PCT four parameters on the platelets before and after treatment in patients with bone marrow ALL compensation cases, efficacy and prognosis of certain diagnostic value.
Key words acute lymphoblastic leukemia; platelet count; mean platelet volume; platelet volume distribution width; platelet hematocrit
Changes and Clinical Significance of Platelet Parameters inPatients with ALL During Chemotherapy
HAN Ri-cheng, ZHONG Cai-ling
(Zhanjiang Central Hospital Affiliated to Guangdong Medical College,
Guangdong Zhanjiang 524037, China)
Abstract: Objective: To observe the changes and the clinical significance of the platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW) and platelet crit (PCT) in acute lymphocytic leukemia (ALL). Method: Ac . T 5diff automated blood cell analyzer was used to test the parameters of blood platelet (PLT / MPV / PDW / PCT) in 67 cases of patients with ALL and compared with 50 cases of health controls. Result: Except for PDW, other 3 indexes were significantly lower in patients with ALL at onset stage than in the controls (P0.05). In the early stage of marrow remission, four indexes were significantly higher than in the marrow restrain plase.Upon the complete remission, 4 indexes were significantly higher in patients of ALL after treatment than in the onset stage (P0.05). Conclusion: It suggested that it is a important value to study the change of four platrlet parameters in the patients of ALL for evaluating the function of bone marrow, the treatment and prognosis during chemotherapy.
Key words: Acute lymphocytic leukemia; Platelet count; Mean platelet volume; P1atelet distribution width; Platelet crit
This observation of 67 cases of acute lymphoblastic leukemia patients before and after chemotherapy PLT, MPV, PDW, PCT changes and parameters of platelets before and after treatment in ALL clinical significance.
1 Subjects and methods
1.1 PARTICIPANTS: February 2007 to February 2009 in our hospital hematology patients diagnosed 67 cases of acute lymphoblastic leukemia as the patient group, 32 male and 35 female, aged 8 to 7
1.2 METHODS: Patients receive appropriate treatment and before beginning the next treatment cycle 1 ~ 2 ml venous blood to the anticoagulant EDTA-K2 mixing tube, 2 h internal BKM Ac.T 5diff automatic completion of five categories of blood platelet analyzer parameter determination. Measured samples, the simultaneous determination of quality control products. Detection of platelet parameters, including PLT, PCT, MPV and PDW. Collected using the same method of detection of the normal physical examination and platelet parameters.
1.3 Statistical analysis: All data are
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Male, 31 years old, Haikou City, Hainan Province Association of Literary Federation cadres. Suffering from aplastic anemia 27 years, after many years and many of the treatment, results are poor, the condition worsen, the final failure to some extent. July 20, 1990 to live our hospital hemoglobin 1.5g, RBC78 million / mm3, PC1.8 million / mm3, WBC1600/mm3, just sick Hb7g (went to Bei Yida, a blood Tianjin, Shanghai Ruijin Hospital, Mongolian, Shandong, Xi'an, Hainan Province, etc.) many a doctor, the medicine has been used, as only a drop of blood instead of all up. Since 1986, cold 2 times sicker, had blood dozens of times. May 1988 lost 11 fetal liver, hemoglobin is still 2-3g, until July 21, 1990 greenish yellow body, dizziness, palpitation, fatigue very, shortness of breath, skin bleeding, tooth Nvxue, tinnitus, nausea, pulse 96 beats / min, the afternoon temperature 37 â„ƒ, after a year living out of our hospit
Male, 21 years old, 9 years chronic aplastic anemia, a detachment of armed police in Hainan Province (570203). In July 1998 patients with disease, yellow, fatigue, body with red spots, the Hainan People's Armed Police Headquarters Hospital, Beijing Army General Hospital Guchuan diagnosed as "chronic aplastic anemia" in Beijing, the Army General Hospital hospital 252 days, hospitalization Hb6g, PC6 million, discharge Hb4.5g, PC minimum 08,000, a total blood transfusion 6 times 400CC, invalid and discharged by the hospital 3 months of treatment with traditional Chinese medicine from blood transfusion, 8 months 50Hb4g rose 9g, PC rose to 56,000 from the 18,000, WBC rose from the 1800 3600, RBC from 162 to rise to 2.7 million, was discharged because of financial difficulties.